The paper explores the actions, activities and processes undertaken by the firms and their start-up entrepreneurs.  A framework for growth is proposed, supporting the notion of the growth process as a complex, multidimensional construct. More specifically, this paper examines the regional variation in startup concentration be used to predict employment in Pennsylvania, Ohio, and West Virginia by metropolitan statistical area (MSA) for the year 2014.  We find significant differences in new firm formation rates from industrial regions to technologically progressive regions using the generalized linear models (GLM). Variations in firm birth rates are explained by industrial size, population growth, the number of startups, human capital variables and establishments.